GB/CHI o46 (-115)
Bills +3 (-125)
Panthers +3 (-110)
With the highest game total on the slate at 52 points and Mahomes being the shot collar in the highest scoring offense in the league makes him an every week play.
With the Jag's hiring of John DeFilippo (formerly of the Vikings) they will move away from a stale offense and try to show off their shiny new toy in Nick Foles. If the 2018 Vikings a signal of things to come expect a much faster offense and either more points or more 3 and outs....both of which equate to more possessions for Mahomes to rack up the points.
With the third highest game total of 50 points Winston will have to sling the ball to keep the Buccaneers in the game.
In 2018 Fitzpatrick and Winston combined to be the QB2 in all of fantasy.
Winston will now have Bruce Arians at the helm, Arians is known to be one of the most fantasy friendly coaches.
The 49ers were 29th in DvP vs QB's last year.